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應用APP首頁(yè) > 應用 > 動(dòng)物行為學(xué)實(shí)驗
血流成像與血氧監測動(dòng)物行為學(xué)實(shí)驗微循環(huán)及血管功能研究長(cháng)時(shí)間動(dòng)態(tài)活細胞觀(guān)察麻醉系統配套方案
步態(tài)分析
時(shí)間:2016-01-05  瀏覽量:11458

步態(tài)分析(Gait Analysis)是以實(shí)驗動(dòng)物為研究對象,根據不同實(shí)驗目的選取相應的動(dòng)物疾病模型或造成該疾病模型,通過(guò)觀(guān)察并記錄實(shí)驗動(dòng)物在該疾病狀態(tài)下的步態(tài)行為學(xué)改變,對相應步態(tài)參數進(jìn)行客觀(guān)、精細、全面地分析統計,進(jìn)而對動(dòng)物模型的藥效學(xué)和(或)毒理學(xué)評價(jià)提供科學(xué)性實(shí)驗依據。目前步態(tài)分析已廣泛應用于老年性疾病,如帕金森氏?。ɑ艔埐綉B(tài))、皮質(zhì)脊髓束病變(痙攣性偏癱步態(tài)和痙攣性截癱步態(tài))、雙側額葉病變(失用步態(tài))、額葉(皮質(zhì)或白質(zhì))病變(小步態(tài))、骨髓損傷性病變(剪刀步態(tài))、錐體外系病變(慌張步態(tài)和扭曲、奇異步態(tài))、小腦病變(共濟失調步態(tài))、小腦病變(舞蹈樣步態(tài))、酒精或巴比妥類(lèi)中毒(醉酒步態(tài))、心因性疾?。Y步態(tài))的研究。

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Yasui D H, Gonzales M L, Aflatooni J O, et al. Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome[J]. Human Molecular Genetics, 2014, 23(9): 2447-2458.

 

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