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應用APP首頁(yè) > 應用 > 動(dòng)物行為學(xué)實(shí)驗
血流成像與血氧監測動(dòng)物行為學(xué)實(shí)驗微循環(huán)及血管功能研究長(cháng)時(shí)間動(dòng)態(tài)活細胞觀(guān)察麻醉系統配套方案
條件性恐懼
時(shí)間:2016-01-05  瀏覽量:14330

條件性恐懼 ( Conditioned Fear) 也稱(chēng)場(chǎng)景恐懼實(shí)驗,是基于巴普洛夫條件反射而建立的一種經(jīng)典的誘導焦慮反應模型的方法。它測定動(dòng)物學(xué)習、記憶不悅經(jīng)歷(aversive experience)和環(huán)境暗示之間關(guān)聯(lián)的能力。常用聲音或光暗示作為條件刺激(conditioning stimulus,CS),以厭惡性刺激(如足電擊)作為非條件刺激(unconditioning stimulus,US),二者配對出現。在條件性恐懼實(shí)驗中動(dòng)物會(huì )表現出一種特有的凝滯(freezing)狀態(tài),通過(guò)觀(guān)察并記錄動(dòng)物的凝滯時(shí)間、凝滯總次數以及活動(dòng)度等相關(guān)參數可以考察其學(xué)習記憶能力和焦慮狀態(tài)。

Gene&I 在十多年的研究與服務(wù)過(guò)程中,積累了豐富的經(jīng)驗,并不斷改進(jìn)產(chǎn)品設計與用戶(hù)體驗,積極探索行為學(xué)的新發(fā)展方向!

Gene&I提供的條件性恐懼分析系統,采用的是動(dòng)物輪廓識別技術(shù)、避免了圖像噪點(diǎn)、雪花等干擾因素,并且提供了嚴格的時(shí)間判據,避免動(dòng)物短時(shí)突動(dòng)對于試驗結果的影響,分析更準確。


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Chao H W, Tsai L Y, Lu Y L, et al. Deletion of CPEB3 Enhances Hippocampus-Dependent Memory via Increasing Expressions of PSD95 and NMDA Receptors[J]. The Journal of Neuroscience, 2013, 33(43): 17008-17022.

 

Zou Y, Corniola R, Leu D, et al. Extracellular superoxide dismutase is important for hippocampal neurogenesis and preservation of cognitive functions after irradiation[J]. PNAS, 2012, 109: 21522 - 21527.

 

Wang I -T J, Allen M, Goffin D, et al. Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice[J]. PNAS, 2012, 109: 21516 – 21521. 


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